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Many of the native peoples died during a smallpox epidemic in 1838.
Settlers also killed several over claims of cattle theft.
Napa County comprises the Napa, CA Metropolitan Statistical Area, which is also included in the San Jose-San Francisco-Oakland, CA Combined Statistical Area. Napa County, once the producer of many different crops, is known today for its regional wine industry, rising to the first rank of wine regions with France by local wineries Stag's Leap Wine Cellars and Chateau Montelena winning the "Judgment of Paris" in 1976.
In prehistoric times, the valley was inhabited by the Patwin Native Americans, with possible habitation by Wappo tribes in the northwestern foothills.
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