On September 26, 2005, he made his debut on All My Children, taking over the role of Josh Madden from his short-lived predecessor Scott Kinworthy.
In 2005, Egglesfield was named one of People magazine's "Sexiest Men Alive".
He transferred to the University of Iowa, where he was in the pre-med program.
After he received his BS from Iowa he backpacked throughout Europe.
Growing up, he was more studious than rambunctious, preferring to spend Friday nights alone building model airplanes.